About

Edward Zhao, Ph.D. is a statistician with over 10 years of experience answering genomics, epidemiology, and other life science questions using statistical and machine learning approaches. Dr. Zhao is currently interested in developing statistical analysis methods for spatial transcriptomics and proteomics technologies. He has work experience in academia, pharma, biotech, and government. Dr. Zhao’s areas of expertise include spatial statistics, GLMs, mixed models, clustering analysis, supervised learning, and Bayesian statistics.

Education

• B.A. in Biochemistry and Mathematical Biology, University of Pennsylvania
• M.S. in Chemistry, University of Pennsylvania
• Ph.D. in Biostatistics, University of Washington - Seattle

Select Publications

Insitutype: likelihood-based cell typing for single cell spatial transcriptomics

Danaher, Patrick, Edward Zhao, Zhi Yang, David Ross, Mark Gregory, Zach Reitz, Tae K. Kim, Sarah Baxter, Shaun Jackson, Shanshan He, Dave Henderson, Joseph M. Beechem. (2022). "Insitutype: likelihood-based cell typing for single cell spatial transcriptomics." bioRxiv.

Spatial transcriptomics at subspot resolution with BayesSpace

Zhao, Edward, Matthew R. Stone, Xing Ren, Jamie Guenthoer, Kimberly S. Smythe, Thomas Pulliam, Stephen R. Williams, Cedric R. Uytingco, Sarah E. B. Taylor, Paul Nghiem, Jason H. Bielas, Raphael Gottardo. (2021). "Spatial transcriptomics at subspot resolution with BayesSpace." Nat. Biotechnol. 39(11).

Salmonella enterica infection of murine and human enteroid-derived monolayers elicits differential activation of epithelium-intrinsic inflammasomes

Holly, Mayumi K., Xiao Han, Edward J. Zhao, Shauna M. Crowley, Joannie M. Allaire, Leigh A. Knodler, Bruce A. Vallance, Jason G. Smith. (2020). "Salmonella enterica infection of murine and human enteroid-derived monolayers elicits differential activation of epithelium-intrinsic inflammasomes." Infect. Immun. 88(7).

Aggregating transcript-level analyses for single-cell differential gene expression

Becht, Etienne, Edward Zhao, Robert Amezquita, Raphael Gottardo. (2020). "Aggregating transcript-level analyses for single-cell differential gene expression." Nat. Methods. 17(6).

Factors associated with exacerbations among adults with asthma according to electronic health record data

Greenblatt, Rebecca E., Edward J. Zhao, Sarah E. Henrickson, Andrea J. Apter, Rebecca A. Hubbard, Blanca E. Himes. (2019). "Factors associated with exacerbations among adults with asthma according to electronic health record data." Asthma Res. Pract. 5(1).

Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis

Chen, Honglei, Edward J. Zhao, Wen Zhang, Yi Lu, Rui Liu, Xuemei Huang, Anna J. Ciesielski-Jones, Michele A. Justice, Deborah S. Cousins, Shyamal Peddada. (2015). "Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis." Transl. Neurodegener. 4(1).